Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNon-Small Cell Lung Cancer
CeRNA1OIP5-AS1[LncRNA]
miRNAmiR-140-5p[miRNA]
CeRNA2HDAC7[mRNA]
Tissue/Cell lineHuman lung cancer cells (A549 and H1299)
SpecieHomo sapiens (human)
CitationOncol Lett 2020 Oct 20, 7 doi:10.3892/ol.2020.11868 PMID:32774481
Reference title
OIP5-AS1 modulates epigenetic regulator HDAC7 to enhance non-small cell lung cancer metastasis via miR-140-5p.
Experimental verification
qRT-PCR,Western blot,luciferase reporter assay etc.
Functional description
In summary, the present study suggested the oncogenic role of lncRNA OIP5-AS1 in NSCLC metastasis via miR-140-5p at the cellular and clinical levels. HDAC7 and VEGFA are two downstream effectors for mediating OIP5-AS1/miR-140-5p-regulated NSCLC metastasis. The present findings may provide an improved understanding of NSCLC progression and accelerate the development of diagnostic and therapeutic strategies for the treatment of NSCLC.
Annotations
External Annotation for OIP5-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
