Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieLung Cancer
CeRNA1TGFB2-AS1[LncRNA]
miRNAmiR-340-5p[miRNA]
CeRNA2EDNRB[mRNA]
Tissue/Cell lineLUAD cells (A549 and PC9) and human lung epithelial cell (BEAS-2B)
SpecieHomo sapiens (human)
CitationAm J Transl Res 2020 12, 3813-3821, PMID:32774737
Reference title
LncRNA TGFB2-AS1 regulates lung adenocarcinoma progression via act as a sponge for miR-340-5p to target EDNRB expression.
Experimental verification
qRT-PCR,Western blot,luciferase reporter assay etc.
Functional description
Taken together, our work indicated TGFB2-AS1 functions as a sponge for miR-340-5p to regulate EDNRB expression in LUAD. These findings identified a novel ceRNA regulatory axis, TGFB2-AS1/miR-340-5p/EDNRB, in LUAD, which will help us to understand the mechanisms behind LUAD progression.
Annotations
External Annotation for TGFB2-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
