Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1LINC00665[LncRNA]
miRNAmiR-9-5p[miRNA]
CeRNA2ATF1[mRNA]
Tissue/Cell lineHuman CRC cell lines (DLD-1, SW480, KM12, SW116 and SW620 cells) and normal colonic epithelial cell line NCM460
SpecieHomo sapiens (human)
CitationHum Cell 2020 Oct 33, 1142-1154 doi:10.1007/s13577-020-00393-z PMID:32776307
Reference title
LINC00665/miR-9-5p/ATF1 is a novel axis involved in the progression of colorectal cancer.
Experimental verification
qRT-PCR,Western blot,luciferase reporter assay,Flow cytometry etc.
Functional description
In summary, we conclude that LINC00665 promotes CRC progression by regulating the miR-9-5p/ATF1 axis, which is expected to expand understanding of the mechanisms of CRC progression and provide potential therapeutic targets for CRC.
Annotations
External Annotation for LINC00665 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
