Basic Information
Regular Relationship :
Tissue/Cell lineHuman glioma cells (U87-MG, A172, U251, and T98G) and humannormal astrocytes normal astrocytes (NHA)
SpecieHomo sapiens (human)
CitationJ Cell Physiol 2021 Feb 236, 1068-1082 doi:10.1002/jcp.29916 PMID:32779194
Reference title
Long noncoding RNA HNF1A-AS1 regulates proliferation and apoptosis of glioma through activation of the JNK signaling pathway via miR-363-3p/MAP2K4.
Experimental verification
qRT-PCR,Flow cytometry,Luciferase reporter assay,Western blot,RIP,ChIP etc.
Functional description
In conclusion, the high expression level of HNF1A-AS1 in gliomatissues and cell lines was activated by transcription factor MYC.Besides this, HNF1A-AS1 worked as a sponge of miR-363-3p topromote cell proliferation and inhibit apoptosis in glioma cells. Inaddition, we proved that HNF1A-AS1 regulates glioma cell growththrough activation of the JNK signaling pathway via the miR-363-3p/MAP2K4 axis.
Annotations
External Annotation for HNF1A-AS1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
