Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCervical Cancer
CeRNA1SNHG1[LncRNA]
miRNAmiR-3127-5p[miRNA]
CeRNA2FZD4[mRNA]
Tissue/Cell lineHeLa and SiHa
SpecieHomo sapiens (human)
CitationExp Biol Med (Maywood) 2021 Jan 246, 20-30 doi:10.1177/1535370220955139 PMID:32883110
Reference title
SNHG1 represses the anti-cancer roles of baicalein in cervical cancer through regulating miR-3127-5p/FZD4/Wnt/b-catenin signaling
Experimental verification
qRT-PCR，Northern blot，Western blot
Functional description
Our findings revealed that SNHG1 represses the antitumorigenic roles of baicalein in CC. Further mechanistic studies revealed that SNHG1 binds miR-3127-5p and functions as a microRNA sponge. Via agglutinating miR-3127-5p, SNHG1 up-regulates FZD4, a target of miR-3127-5p. Through up-regulating FZD4, SNHG1 further activates Wnt/b-catenin signaling. Collectively, these data presented that SNHG1 represses the antitumorigenic roles of baicalein in CC through modulating miR-3127-5p/FZD4/Wnt/b-catenin axis.
Annotations
External Annotation for SNHG1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
