Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieBreast Cancer
CeRNA1MALAT1[LncRNA]
miRNAmiR-143-D14733p[miRNA]
CeRNA2RALGAPA2[mRNA]
Tissue/Cell linebreast cancer cell lines,tumor-derived cell lines
SpecieHomo sapiens (human)
CitationHum Cell 2020 Oct 33, 1229-1239 doi:10.1007/s13577-020-00422-x PMID:32880825
Reference title
The interaction between MALAT1 target, miR1433p, and RALGAPA2 is afected by functional SNP rs3827693 in breast cancer
Experimental verification
qPCR
Functional description
MALAT1 has been shown to promote breast cancer development and progression via repressing diferent RNA molecules such as miR-1, CDC42 [16], CD133 [17] and miR-448 [18]. In this study, we aimed to fnd more down-stream target(s) of MALAT1 in breast cancer. Here, we use a computational approach to shortlist the potential targets of MALAT1 and show that MALAT1 negatively correlates with miR-143-3p in clinical breast cancer samples. We then, fnd RALGAPA2 as a potential and novel target of miR-143-3p.
Annotations
External Annotation for MALAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
