Basic Information
Regular Relationship :
Phenotype/DiseaseSpeciePituitary Adenoma
CeRNA1SNHG7[LncRNA]
miRNAmiR-449a[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineRat pituitary, GH1, RC-4B/C, GH3 and MMQ
SpecieHomo sapiens (human)
CitationMetab Brain Dis 2021 Jan 36, 123-132 doi:10.1007/s11011-020-00611-5 PMID:32880813
Reference title
LncRNA SNHG7 sponges miR-449a to promote pituitary adenomas progression
Experimental verification
qPCR,Luciferase reporter assay
Functional description
We demonstrated that SNHG7-silencing delayed xenograft tumor progression, which was accompanied with increased miR-449a and decreased Ki67 intensity. Our study highlighted the essential oncogenic properties of the SNHG7/miR-449a axis in pituitary adenoma.
Annotations
External Annotation for SNHG7 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
