Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieEsophageal Squamous Cancer
CeRNA1TTTY15[LncRNA]
miRNAmiR-337-3p[miRNA]
CeRNA2JAK2[mRNA]
Tissue/Cell lineEC109, EC9706, TE-1, TE-3,HET-1A
SpecieHomo sapiens (human)
CitationAnticancer Drugs 2020 Nov 31, 1038-1045 doi:10.1097/cad.0000000000000960 PMID:32868648
Reference title
Long noncoding RNA TTTY15 promotes growth and metastasis of esophageal squamous cell carcinoma by sponging microRNA-337-3p to upregulate the expression of JAK2
Experimental verification
qRT-PCR,Luciferase reporter assay,Western blot
Functional description
We explored the potential role of TTTY15 and the related mechanism in ESCC. We found that TTTY15 was upregulated in tissues of male patients with ESCC, and in-vitro study proved that TTTY15 could regulate the proliferation and metastasis of ESCC cells. Additionally, we further demonstrated that TTTY15 could upregulate JAK2 expression as a ‘competing endogenous RNA (ceRNA)’ for miR-337-3p, thus playing an oncogenic role in the pathogenesis of ESCC.
Annotations
External Annotation for TTTY15 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
