Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCutaneous Squamous Cell Carcinoma
CeRNA1PICSAR[LncRNA]
miRNAmiR-125b[miRNA]
CeRNA2YAP1[mRNA]
Tissue/Cell lineSCL-1 and SCC13;HaCaT
SpecieHomo sapiens (human)
CitationLife Sci 2021 Jun 1 274, 118303 doi:10.1016/j.lfs.2020.118303 PMID:32841663
Reference title
Long non-coding RNA PICSAR knockdown inhibits the progression of cutaneous squamous cell carcinoma by regulating miR-125b/YAP1 axis.
Experimental verification
qPCR;luciferase reporter assays;Western blot
Functional description
Moreover, miR-125b could directly bind to PICSAR and its inhibition reversed the effect of PICSAR knockdown on proliferation, invasion and apoptosis in CSCC cells. In addition, YAP1 was a direct target of PICSAR and its overexpression attenuated the anti-cancer role of miR-125b in CSCC cells.
Annotations
External Annotation for PICSAR |
|
|---|---|
 |
LncRNA-associated competing triplets and functions. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
 |
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
 |
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
 |
Information on all annotated and predicted human genes. |
 |
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
 |
Genome browser for vertebrate genomes. |
 |
An annotated collection of all publicly available DNA sequences. |
 |
A wiki-based platform for community curation of human long non-coding RNAs. |
 |
An integrated knowledge database dedicated to non-coding RNAs. |
 |
An integrated database of human annotated lncRNA transcripts. |
 |
Comprehensive annotations of eukaryotic long non-coding RNAs. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
 |
The catalogue of somatic mutations in cancer. |
