Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1SNHG6[LncRNA]
miRNAmiR-181[miRNA]
CeRNA2JAK2[mRNA]
Tissue/Cell lineHT29, HCT8, SW480 and HCT116 as well as FHC cell line
SpecieHomo sapiens (human)
CitationJ Gene Med 2020 Dec 22, e3262 doi:10.1002/jgm.3262 PMID:32840014
Reference title
Long non-coding RNA SNHG6 increases JAK2 expression by targeting miR-181 family to promote colorectal cancer cell proliferation.
Experimental verification
qRT-PCR;luciferase reporter assays;Western blot
Functional description
Moreover, over-expressed SNHG6 significantly counteracted the inhibitory effect of miR-181 mimics on CRC cell proliferation as well as the promoting effect on apoptosis. Furthermore, SNHG6 over-expression and knock-down can promote and inhibit JAK2 expression, respectively, and miR-181 family members' function is opposite to SNHG6 by repressing JAK2.
Annotations
External Annotation for SNHG6 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
