Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCardiac Ischemia Reperfusion Injury
CeRNA1TUG1[LncRNA]
miRNAmiR-532-5p[miRNA]
CeRNA2Sox8[mRNA]
Tissue/Cell lineH9c2 cells
SpecieHomo sapiens (human)
CitationJ Cardiovasc Pharmacol 2020 Nov 76, 556-563 doi:10.1097/fjc.0000000000000895 PMID:32833900
Reference title
LncRNA TUG1 knockdown protects cardiomyocytes against hypoxia/reoxygenation-induced injury via regulating miR-532-5p/Sox8 axis.
Experimental verification
qRT-PCR;luciferase reporter assays;Western blot
Functional description
UG1 directly bound to miR-532-5p, and miR-532-5p inhibition reversed the action of TUG1 knockdown on H/R-induced cardiomyocyte injury. Sox8 was a target of miR-532-5p, and miR-532-5p blunted H/R-induced cardiomyocyte injury by targeting Sox8. Additionally, TUG1 knockdown inhibited H/R-induced Sox8 elevation via miR-532-5p in H9c2 cells. TUG1 silence ameliorated H/R-induced cardiomyocytes injury via regulating miR-532-5p/Sox8 axis, suggesting a potential therapeutic target for preventing myocardial ischaemia/reperfusion injury.
Annotations
External Annotation for TUG1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
