Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieSepsis-Induced Acute Lung Injury
CeRNA1THRIL[LncRNA]
miRNAmiR-424[miRNA]
CeRNA2ROCK2[mRNA]
Tissue/Cell lineMPVECs
SpecieHomo sapiens (human)
CitationMol Immunol 2020 Oct 126, 111-119 doi:10.1016/j.molimm.2020.07.021 PMID:32818819
Reference title
LncRNA THRIL aggravates sepsis-induced acute lung injury by regulating miR-424/ROCK2 axis.
Experimental verification
qRT-PCR;luciferase reporter assays;Western blot
Functional description
MiR-424 and Rho-associated kinase 2 (ROCK2) were predicted and verified as direct targets of THRIL and miR-424, respectively, by using dual-luciferase reporter assay. ROCK2 overexpression vector and shTHRIL were co-transfected into mouse pulmonary microvascular endothelial cells for 24 h before LPS treatment. Our results showed that THRIL was highly expressed in the lung of sepsis mice.
Annotations
External Annotation for THRIL |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
