Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNon-Small Cell Lung Cancer
CeRNA1HCG11[LncRNA]
miRNAmiR-875[miRNA]
CeRNA2SATB2[mRNA]
Tissue/Cell lineA549, H1299, H466, H460 and H358
SpecieHomo sapiens (human)
CitationMol Med Rep 2021 Aug 24 doi:10.3892/mmr.2021.12191 PMID:34080031
Reference title
Long non-coding RNA HCG11 suppresses the malignant phenotype of non-small cell lung cancer cells by targeting a miR-875/SATB2 axis
Experimental verification
qRT-PCR;luciferase reporter assays;Western blot
Functional description
Patients with high HCG11 expression had an increased survival rate compared with patients with low HCG11 expression. Further studies have shown that overexpression of HCG11 inhibited NSCLC cell proliferation in vitro and in vivo. Interestingly, it was observed that HCG11 expression was negatively associated with the expression levels of oncogenic microRNA-875 (miR-875) in patient specimens. Specifically, HCG11 served as a sponge of miR-875. Notably, it was determined that special AT-rich sequence-binding protein 2 (SATB2) was a direct target gene of miR-875, and overexpression of miR-875 largely abrogated the effects of HCG11 in NSCLC cells. In conclusion, HCG11 was shown to suppress the malignant properties of NSCLC cells by targeting a miR-875/SATB2 axis, and may therefore be a promising target for the treatment of NSCLC.
Annotations
External Annotation for HCG11 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
