Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNon-Small Cell Lung Cancer
CeRNA1NEAT1[LncRNA]
miRNAmiR-335[miRNA]
CeRNA2c-Met[mRNA]
Tissue/Cell lineA549 and PC9 cells
SpecieHomo sapiens (human)
CitationJ buon 2021 Mar-Apr 26, 345-352, PMID:34076978
Reference title
Long noncoding RNA NEAT1 aggravates sorafenib-resistance in non-small cell lung cancer via regulating miRNA-335/c-Met
Experimental verification
qRT-PCR;luciferase reporter assays;Western blot; RIP assays
Functional description
Sorafenib treatment in A549 cells and PC9 cells attenuated the proliferation and induced apoptosis, which were more pronounced after silencing of NEAT1. MiR-335 was the downstream target of NEAT1, and its level was negatively regulated by NEAT1. Moreover, c-Met was the target gene of MiR -335. Rescue experiments verified the role of NEAT1/ MiR-335/c-Met regulatory loop in reducing the proliferative ability and inducing apoptosis of sorafenib-treated lung cancer cells.
Annotations
External Annotation for NEAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
