LncACTdb 3.0

miRNA

CeRNA2

AKT2[mRNA]

Tissue/Cell line

bone marrow cells,Jurkat,6T-CEM,Nalm-6,293T

Specie

Homo sapiens (human)

Citation

Front Cell Dev Biol 2021 9, 639910 doi:10.3389/fcell.2021.639910 PMID:34055775

Reference title

Mechanism of circADD2 as ceRNA in Childhood Acute Lymphoblastic Leukemia

Experimental verification

qRT-PCR;Dual-luciferase reporter assay;Western blot;

Functional description

circADD2, as a tumor suppressor in ALL, can sponge miR-149-5p, and may serve as a potential biomarker for the diagnosis or treatment of ALL.

External Annotation for CircADD2
	LncRNA-associated competing triplets and functions.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	Infer genomic variations that disturb lncRNA-associated ceRNA regulation..
	Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements.
	Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data.
	Information on all annotated and predicted human genes.
	Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).
	Genome browser for vertebrate genomes.
	An annotated collection of all publicly available DNA sequences.
	A wiki-based platform for community curation of human long non-coding RNAs.
	An integrated knowledge database dedicated to non-coding RNAs.
	An integrated database of human annotated lncRNA transcripts.
	Comprehensive annotations of eukaryotic long non-coding RNAs.
	Comprehensive experimentally supported associations between lncRNA and human cancer.
	A comprehensive, authoritative compendium of human genes and genetic phenotypes.
	The catalogue of somatic mutations in cancer.

Detail (Experimental CeRNA)