Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieAtrial Fibrosis
CeRNA1NEAT1[LncRNA]
miRNAmiR-320[miRNA]
CeRNA2NPAS2[mRNA]
Tissue/Cell lineCardiac fibroblast
SpecieHomo sapiens (human)
CitationFront Pharmacol 2021 12, 647124 doi:10.3389/fphar.2021.647124 PMID:34040522
Reference title
LncRNA Nuclear-Enriched Abundant Transcript 1 Regulates Atrial Fibrosis via the miR-320/NPAS2 Axis in Atrial Fibrillation
Experimental verification
qRT-PCR;Luciferase Activity Assay;Western blot
Functional description
We demonstrated that NEAT1 could negatively regulate miR-320 expression by acting as a competitive endogenous RNA (ceRNA). miR-320 directly targeted neuronal per arnt sim domain protein 2 (NPAS2) and suppressed its expression. We observed that NEAT1 exerted its function via the miR-320-NPAS2 axis in cardiac fibroblasts. These findings indicate that NEAT1 exerts a significant effect on atrialfibrosis and that this lncRNA is a new potential molecular target for AF treatment.
Annotations
External Annotation for NEAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
