Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieBladder Cancer
CeRNA1MEG3[Protein]
miRNAmiR-141[miRNA]
CeRNA2SCARA5[mRNA]
Tissue/Cell lineNormal bladder cell line, SV-HUC-1 and BC cell lines
SpecieHomo sapiens (human)
CitationLife Sci 2021 May 17, 10.1016/j.lfs.2021.119619, 119619 doi:10.1016/j.lfs.2021.119619 PMID:34015283
Reference title
SCARA5 regulated by MEG3/miR-141 axis attenuates proliferation, migration and invasion of bladder cancer
Experimental verification
qRT-PCR;luciferase reporter assays;Western blot
Functional description
MEG3 suppressed proliferation, decreased invasive and migrative cell number of BC cells at least partly via sponging miR-141. The tumor suppressive effects of SCARA5 were positive regulated by MEG3. Luciferase activity assay indicated that MEG3 targeted miR-141 and miR-141 targeted SCARA5.
Annotations
External Annotation for MEG3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
