Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieMcmv Infection
CeRNA1viral transcript m169[Viral RNA]
miRNAmiR-27b[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineMurine Embryonic Fibroblasts And Bone Marrow Stroma Cells
SpecieMurid herpesvirus 1 (murine cytomegalovirus)
CitationPLoS Pathog 2012 Feb 8, e1002510 doi:10.1371/journal.ppat.1002510 PMID:22346748
Reference title
Degradation of Cellular miR-27 by a Novel, Highly Abundant Viral Transcript Is Important for Efficient Virus Replication In Vivo
Experimental verification
qRT-PCR;luciferase reporter assays;Northern blot
Functional description
In this paper, we show that their regulation is mediated by the highly abundant viral transcript m169. It targets miR-27a/b via a single binding site in its 3'-UTR, which can be efficiently retargeted to other cellular and viral miRNAs, enabling the efficient knock-down of individual miRNAs of interest. Degradation of miR-27a/b is preceded by its 3'-tailing and -trimming.
Annotations
External Annotation for viral transcript m169 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
