Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNA
CeRNA1anti-miR-122 TuD[Artifically engineered RNA]
miRNAmiR-122[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineLiver, Heart
SpecieMus musculus (mouse)
CitationNat Methods 2012 Mar 4 9, 403-9 doi:10.1038/nmeth.1903 PMID:22388288
Reference title
Long-term, efficient inhibition of microRNA function in mice using rAAV vectors
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
To accelerate analysis of miRNA biology in mammals, we combined recombinant adeno-associated virus (rAAV) vectors with miRNA tough decoys (TuDs) to inhibit specific miRNAs. rAAV producing anti-miR-122 TuD but not anti-let-7 TuD reduced serum cholesterol by >30% for 25 weeks in wild-type mice.
Annotations
External Annotation for anti-miR-122 TuD |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
