Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHerpesviruses
CeRNA1anti-miR-BART2-5p-sponge[Artifically engineered RNA]
miRNAmiR-BART2-5p(EBV)[miRNA]
CeRNA2MICB[mRNA]
Tissue/Cell lineHuman B Cell Lines
SpecieHomo sapiens (human)
CitationCell Host Microbe 2009 Apr 23 5, 376-85 doi:10.1016/j.chom.2009.03.003 PMID:19380116
Reference title
Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells.
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
Here, we show functional conservation amongdiverse microRNAs derived from different herpesviruses, including HCMV, Kaposis sarcoma-associated herpesvirus (KSHV), and Epstein-Barr virus (EBV), in their ability to directly target MICB mRNA and reduce its expression. Although the various viral microRNAs share no sequence homology, they are functionally similar and target MICB at different yet adjacent sites during authentic viral infection. The finding that different herpesvirus microRNAs target MICB indicates that MICB plays a pivotal role in the clash between herpesviruses and humans.
Annotations
External Annotation for anti-miR-BART2-5p-sponge |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
