Basic Information
Regular Relationship :
Tissue/Cell lineglioma cells
SpecieHomo sapiens (human)
CitationCell Biochem Biophys. 2021 Jun 11. doi: 10.1007/s12013-021-01007-7.
Reference title
Suppression of lncRNA HOXA11-AS/miR-124 Axis Inhibits Glioma Progression.
Experimental verification
qRT-PCR
Functional description
Our aim was to clarify the regulations of lncRNA HOXA11-AS (HOXA11-AS) played on the progression of glioma as well as to investigate the mechanisms by which HOXA11-AS modulated development of glioma. This study confirmed the regulations of miR-124 and HOXA11-AS on the progression of glioma. Here, HOXA11-AS was overexpressed and miR-124 was underexpressed in glioma. Expression of miR-124 was negatively related to that of HOXA11-AS. Silencing of HOXA11-AS suppressed cell proliferation, invasion, and promoted apoptosis in glioma cells in vitro. Moreover, inhibition of HOXA11-AS expression repressed glioma xenograft tumor growth. Expression of miR-124 was repressed by HOXA11-AS functioning as sponge. In addition, miR-124 knockdown partially abolished the inhibitory roles of HOXA11-AS downregulation in glioma cells. Conclusively, this study suggested that silencing of HOXA11-AS restrained proliferation, invasion, induced apoptosis of glioma cells, and repressed xenograft growth via modulating miR-124 expression and thus inhibited glioma progression.
Annotations
External Annotation for HOXA11-AS |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
