Basic Information
Regular Relationship :
Tissue/Cell lineHl-7702, Huh-1, Huh-4, Hep3B, Hepg2, Huh-7, Snu-449, Snu-475
SpecieHomo sapiens (human)
CitationNucleic Acids Res 2010 Sep 38, 5366-83 doi:10.1093/nar/gkq285 PMID:20423907
Reference title
CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays;Chromatin immunoprecipitation assays
Functional description
We demonstrated HULC may act as an endogenous sponge, which down-regulates a series of microRNAs (miRNAs) activities, including miR-372. Inhibition of miR-372 leads to reducing translational repression of its target gene, PRKACB, which in turn induces phosphorylation of CREB.
Annotations
External Annotation for HULC |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
