Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGlioblastoma
CeRNA1VAPA[Coding-mRNA]
miRNAmiR-106a[miRNA]
CeRNA2PTEN[mRNA]
Tissue/Cell lineDu145 Prostate Cancer Cells, Glioblastoma
SpecieHomo sapiens (human)
CitationCell 2011 Oct 14 147, 344-57 doi:10.1016/j.cell.2011.09.029 PMID:22000013
Reference title
Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
A combined computational and experimental approach has been used to identify CNOT6L and VAPA as protein-coding transcripts that regulate PTEN transcript and protein expression in a Dicer-dependent manner, antagonize downstream PI(3)K signalling and possess growth- and tumour-suppressive properties
Annotations
External Annotation for VAPA |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
