Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieAstrocytoma
CeRNA1FN1[Coding-mRNA]
miRNAmiR-199a-3p[miRNA]
CeRNA2VCAN[mRNA]
Tissue/Cell lineAstrocytoma Cell Line U343
SpecieHomo sapiens (human)
CitationPLoS One 2009 4, e4527 doi:10.1371/journal.pone.0004527 PMID:19223980
Reference title
A 3 -untranslated region (3 UTR) induces organ adhesion by regulating miR-199a* functions.
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
Computational analysis indicated that a large number of microRNAs could bind to this fragment potentially including miR-199a*. Expression of versican and fibronectin, two targets of miR-199a*, are up-regulated in transgenic mice, suggesting that the 3UTR binds and modulates miR-199a* activities, freeing mRNAs of versican and fibronectin from being repressed by miR-199a*. Confirmation of the binding was performed by PCR using mature miR-199a* as a primer and the targeting was performed by luciferase assays. Enhanced adhesion by expression of the 3UTR was confirmed by in vitro assays.
Annotations
External Annotation for FN1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
