Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHcv Infection
CeRNA1Miravirsen[Artifically engineered RNA]
miRNAmiR-122[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineLiver Tissues
SpecieHomo sapiens (human)
CitationN Engl J Med 2013 May 2 368, 1685-94 doi:10.1056/NEJMoa1209026 PMID:23534542
Reference title
Treatment of HCV infection by targeting microRNA.
Experimental verification
qRT-PCR
Functional description
Miravirsen is a 15-nucleotide locked nucleic acid–modified antisense oligonucleotide complementary to and with a high affinity and specificity for the 5' region of mature miR-122. Miravirsen can sequester and thus inhibit miR-122 Mechanism of Action of Miravirsen.). The administration of miravirsen to chimpanzees with chronic HCV infection provided long-lasting viral suppression without evidence of resistant mutations at the two miR-122 binding sites of the 5' untranslated region of the HCV genome, and no adverse events were observed in phase 1 studies in healthy volunteers.16,17 Here, we report on the safety and activity of miravirsen in patients with chronic HCV infection.
Annotations
External Annotation for Miravirsen |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
