Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieProstate Cancer
CeRNA1CDK4PS[Pseudogene]
miRNAmiR-34[miRNA]
CeRNA2CDK4[mRNA]
Tissue/Cell linePhoenix A, 293T And Pc3
SpecieHomo sapiens (human)
CitationNature 2010 Jun 24 465, 1033-8 doi:10.1038/nature09144 PMID:20577206
Reference title
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
To extend our studies beyond PTEN and its pseudogene, we examined other cancer-related pseudogenes and genes. Alignments of gene and pseudogenes sequences show that microRNA-binding sites are well conserved; for example, the miR-145 binding site on OCT4 and its pseudogenes OCT4-pg1, 3, 4 and 5; miR-1 family binding sites on CONNEXIN 43 (CX43) and its pseudogene. Notably, OCT4-pg1 and -pg5 are exclusively expressed in cancer tissues and not in normal tissues17. Furthermore OCT4-pg5 is truncated at the 5’ end and expresses only a partial open reading frame region followed by the 3’UTR. Further examples of such conservation include: miR-34 family binding site on CDK4PS; miR-182 binding site on FOXO3B; miR-17 family binding site on E2F3P1; miR-143 and let-7 family binding sites on KRAS1P.
Annotations
External Annotation for CDK4PS |
|
|---|---|
 |
LncRNA-associated competing triplets and functions. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
 |
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
 |
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
 |
Information on all annotated and predicted human genes. |
 |
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
 |
Genome browser for vertebrate genomes. |
 |
An annotated collection of all publicly available DNA sequences. |
 |
A wiki-based platform for community curation of human long non-coding RNAs. |
 |
An integrated knowledge database dedicated to non-coding RNAs. |
 |
An integrated database of human annotated lncRNA transcripts. |
 |
Comprehensive annotations of eukaryotic long non-coding RNAs. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
 |
The catalogue of somatic mutations in cancer. |
