Basic Information
Regular Relationship :
Tissue/Cell lineInsulin-Secreting Cells
SpecieHomo sapiens (human)
CitationNat Commun. 2021 Jun 28;12(1):3997. doi: 10.1038/s41467-021-24302-6.
Reference title
The long non-coding RNA bFaar regulates islet b-cell function and survival during obesity in mice.
Experimental verification
qRT-PCR
Functional description
Despite obesity being a predisposing factor for pancreatic b-cell dysfunction and loss, the mechanisms underlying its negative effect on insulin-secreting cells remain poorly understood. In this study, we identify an islet-enriched long non-coding RNA (lncRNA), which we name b-cell function and apoptosis regulator (bFaar). bFaar is dramatically downregulated in the islets of the obese mice, and a low level of bFaar is necessary for the development of obesity-associated b-cell dysfunction and apoptosis. Mechanistically, bFaar promote the synthesis and secretion of insulin by upregulating islet-specific genes Ins2, NeuroD1, and Creb1 through sponging miR-138-5p. In addition, using quantitative mass spectrometry, we identify TRAF3IP2 and SMURF1 as interacting proteins that are specifically associated with bFaar. We demonstrate that SMURF1 ubiquitin ligase activity is essential for TRAF3IP2 ubiquitination and activation of NF-kB-mediate b-cell apoptosis. Our experiments provide direct evidence that dysregulated bFaar contributes to the development of obesity-induced b-cell injury and apoptosis.
Annotations
External Annotation for bFaar |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
