Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieOvarian Cancer
CeRNA1SNAI1[Coding-mRNA]
miRNAmiR-203[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineRmug-L Cell Line
SpecieHomo sapiens (human)
CitationTumour Biol 2015 Feb 36, 1067-72 doi:10.1007/s13277-014-2733-z PMID:25326810
Reference title
The SNAI1 3'UTR functions as a sponge for multiple migration-/invasion-related microRNAs.
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
Since SNAI1 3'UTR primarily influenced migration and invasion of RMUG-L cells, we narrowed our search to miRNAs that have been demonstrated to have contributions to migration and invasion in ovarian cancer or other cancers. Namely, seven candidate miRNAs including miR-153, miR-199a-5p, miR-203, miR-204, miR-22, miR-34a, and miR-34c were subjected to further validation.Luciferase assays indicated that decreased activity of miR-153, miR-199a, miR-203, miR-204, miR-22 and miR-34c resulted from increased levels of Renilla luciferase after SNAI1 3'UTR overexpression in RMUG-L cells.
Annotations
External Annotation for SNAI1 |
|
|---|---|
 |
LncRNA-associated competing triplets and functions. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
 |
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
 |
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
 |
Information on all annotated and predicted human genes. |
 |
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
 |
Genome browser for vertebrate genomes. |
 |
An annotated collection of all publicly available DNA sequences. |
 |
A wiki-based platform for community curation of human long non-coding RNAs. |
 |
An integrated knowledge database dedicated to non-coding RNAs. |
 |
An integrated database of human annotated lncRNA transcripts. |
 |
Comprehensive annotations of eukaryotic long non-coding RNAs. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
 |
The catalogue of somatic mutations in cancer. |
