Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieNA
CeRNA1FC sponge[Artifically engineered RNA]
miRNAmiR-9[miRNA]
CeRNA2REST[mRNA]
Tissue/Cell lineBrain Tissues
SpecieMus musculus (mouse)
CitationElife 2014 Nov 18 3 doi:10.7554/eLife.02755 PMID:25406064
Reference title
MicroRNA-9 controls dendritic development by targeting REST.
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
In order to target miR-9 in vivo, we developed a transgenic miRNA sponge mouse line allowing conditional inactivation of the miR-9 family in a spatio-temporal-controlled manner. Using this novel approach, we found that the sponge variants displayed similar efficacies to inhibit miR-9 activity
Annotations
External Annotation for FC sponge |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
