Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCellular Antiviral Response
CeRNA1HCV RNA[Viral RNA]
miRNAmiR-122[miRNA]
CeRNA2STAT3[mRNA]
Tissue/Cell lineHuh7 Cells
SpecieHomo sapiens (human)
CitationMol Med Rep 2015 Mar 11, 1733-7 doi:10.3892/mmr.2014.2897 PMID:25377467
Reference title
Hepatitis C virus represses the cellular antiviral response by upregulating the expression of signal transducer and activator of transcription 3 through sponging microRNA-122.
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
miR-122 inhibited the expression of signal transducer and activator of transcription 3 (STAT3), an antivirus response repressor.The HCV RNA acted as an miRNA sponge, which upregulated the expression of STAT3 by sealing miR-122.
Annotations
External Annotation for HCV RNA |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
