Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieWound Repair And Fibroblast
CeRNA1VCAN[Coding-mRNA]
miRNAmiR-680[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineFibroblasts
SpecieMus musculus (mouse)
CitationBiochim Biophys Acta 2014 Jul 1843, 1373-85 doi:10.1016/j.bbamcr.2014.02.015 PMID:24594381
Reference title
Versican 3'-untranslated region (3'UTR) promotes dermal wound repair and fibroblast migration by regulating miRNA activity
Experimental verification
Western blot;qRT-PCR;luciferase reporter assays
Functional description
We demonstrated that both the versican 3'UTR and b-catenin 3'UTR shared common binding sites for miR-185, miR-203*, miR-434-3p, miR-680, and miR-690. It appeared that over-expression of the versican 3'UTR bound and inhibited the activity of these miRNAs, resulting in promotion of versican expression and b-catenin expression.
Annotations
External Annotation for VCAN |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
