Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1HBx[Protein]
miRNAmiR-148a[miRNA]
CeRNA2ERK[mRNA]
Tissue/Cell lineLiver Tissues
SpecieMus musculus (mouse)
CitationCancer Biol Med 2014 Sep 11, 182-90 doi:10.7497/j.issn.2095-3941.2014.03.004 PMID:25364579
Reference title
Hepatitis B virus X protein accelerates the development of hepatoma.
Experimental verification
qRT-PCR
Functional description
HBx suppresses the p53-mediated activation of miR-148a, resulting in the upregulation of AKT and ERK and subsequent activation of mTOR to promote cancer growth and metastasis in a mouse model of HCC.
Annotations
External Annotation for HBx |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
