Basic Information
Regular Relationship :
Tissue/Cell lineSkov3, Omc685, A2780 And Ho8910
SpecieHomo sapiens (human)
CitationOncol Res 2018 Mar 5 26, 241-247 doi:10.3727/096504017x14953948675412 PMID:28550684
Reference title
Long Noncoding RNA CCAT2 Knockdown Suppresses Tumorous Progression By Sponging miR-424 in epithelial Ovarian Vancer.
Experimental verification
luciferase reporter assays;qRT-PCR
Functional description
CCAT2 knockdown induced by interfering oligonucleotides could inhibit proliferation and promote apoptosis and induce cell cycle arrest at G0/G1 phase. Bioinformatics prediction analysis predicted that miR-424 targeted CCAT2, which was confirmed by luciferase reporter assay. Moreover, miR-424 inhibitor rescued the tumorigenesis inhibition induced by CCAT2 knockdown.
Annotations
External Annotation for CCAT2 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
