Basic Information
Regular Relationship :
Tissue/Cell lineHuman Thyroid Follicular Epithelial Cell Line
SpecieHomo sapiens (human)
CitationAm J Transl Res 2017 9, 2181-2194, PMID:28559970
Reference title
The lncRNA n340790 accelerates carcinogenesis of thyroid cancer by regulating miR-1254.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
we found that n340790 was highly expressed, miR-1254 exhibited low levels of expression in human thyroid cancer tissues, and both of these molecules were good prognostic factors for thyroid cancer. n340790 and miR-1254 were simultaneously and strongly correlated with invasion, metastasis, and TNM stage of thyroid cancer. n340790 plays vital roles in the development of thyroid cancer both in vitro and in vivo. Furthermore, n340790 could act as an endogenous sponge by directly binding to miR-1254 and decreasing miR-1254 expression.
Annotations
External Annotation for n340790 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
