Basic Information
Regular Relationship :
Tissue/Cell lineHela, Caski, Siha, Ht-3 And C33A
SpecieHomo sapiens (human)
CitationOncol Res 2018 Apr 10 26, 345-352 doi:10.3727/096504017x14953948675449 PMID:28550682
Reference title
Long Noncoding RNA ANRIL Promotes Cervical Cancer Development By Acting as a Sponge of miR-186.
Experimental verification
luciferase reporter assays;qRT-PCR
Functional description
RT-PCR showed that ANRIL expression was significantly up-regulated in cervical cancer tumors and cell lines. Nevertheless, ANRIL knockdown transfected with interference oligonucleotide inhibited the proliferation activity and invasive ability, and promoted apoptosis of cervical cancer cell lines. Bioinformatics prediction program and luciferase assay predicted and validated that miR-186 directly targeted ANRIL. Expression level of miR-186 was down-regulated in cervical cancer tumors and cell lines and negatively correlated to that of ANRIL. Moreover, rescue experiments showed that miR-186 inhibitor could reverse the suppression of ANRIL knockdown.
Annotations
External Annotation for ANRIL |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
