Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieEndothelial-To-Mesenchymal Transition
CeRNA1MALAT1[LncRNA]
miRNAmiR-145[miRNA]
CeRNA2TGFB1[mRNA]
Tissue/Cell lineEndothelial Progenitor Cells
SpecieHomo sapiens (human)
CitationCell Physiol Biochem 2017 42, 357-372 doi:10.1159/000477479 PMID:28535533
Reference title
MALAT1 Modulates TGF-b1-Induced endothelial-to-mesenchymal transition through Downregulation of miR-145.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
Expression levels of EndMT markers were assessed by qRT-PCR and western blotting. Alpha-smooth muscle actin (a-SMA) expression was measured by cell immunofluorescence staining. The regulatory relationship between MALAT1 and miR-145 and its target genes, TGFBR2 (TGFb receptortype II) and SMAD3 (mothers against decapentaplegic homolog 3) was analyzed using the luciferase reporter assay.
Annotations
External Annotation for MALAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
