Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieLung Cancer
CeRNA1lincRNA-ROR[LncRNA]
miRNAmiR-145[miRNA]
CeRNA2Sox2[mRNA]
Tissue/Cell lineLung Cancer Stem Cell
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2017 May 18, 10.1002/jcb.25960 doi:10.1002/jcb.25960 PMID:28516515
Reference title
Interaction of lincRNA ROR and p53/miR-145 correlates with lung cancer stem cell signatures.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot
Functional description
high p53 level, low miR-145 level, and high ROR level were associated with poor prognosis in NSCLC.silencing ROR failed to change p53 mRNA level but promoted p53 protein level, suggesting a posttranscriptional regulation mechanism involved in si-ROR-mediated promotion of p53. While silencing p53 moderately downregulated ROR. Additionally, silencing ROR or p53 upregulated miR-145. However, silencing both ROR and p53 failed to make obvious change to miR-145 mRNA level and p53 protein level.
Annotations
External Annotation for lincRNA-ROR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
