Basic Information
Regular Relationship :
Phenotype/DiseaseSpeciePapillary Thyroid Cancer
CeRNA1PTCSC3[LncRNA]
miRNAmiR-574-5p[miRNA]
CeRNA2SCAI[mRNA]
Tissue/Cell linePtc-1 Cells
SpecieHomo sapiens (human)
CitationJ Cell Biochem 2017 Dec 118, 4745-4752 doi:10.1002/jcb.26142 PMID:28513866
Reference title
LncRNA PTCSC3/miR-574-5p governs cell proliferation and migration of papillary thyroid carcinoma via Wnt/b-catenin signaling.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot
Functional description
Overexpressed PTCSC3 suppressed cell proliferation and migration, promoted the expression of SCAI, but inhibited b-catenin. PTCSC3 absorbed miR-574-5p, and miR-574-5p targeted to SCAI; SCAI could regulate the activity of Wnt/b-catenin. PTCSC3/miR-574-5p regulated the activity of Wnt/b-catenin via SCAI and mediated cell proliferation and migration of PTC-1.
Annotations
External Annotation for PTCSC3 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
