Basic Information
Regular Relationship :
Tissue/Cell lineMelanoma Cells
SpecieHomo sapiens (human)
CitationOncol Res 2018 Mar 5 26, 201-208 doi:10.3727/096504017x14920318811749 PMID:28409554
Reference title
LncRNA CCAT1 Upregulates Proliferation and Invasion in Melanoma Cells Via Suppressing miR-33a.
Experimental verification
luciferase reporter assays;qRT-PCR
Functional description
Expression of CCAT1 was significantly up-regulated in melanoma tissue and cell lines. CCAT1 knockdown observably suppressed the proliferation, migration and invasion ability. Bioinformatics analysis predicted that miR-33a acted as target of CCAT1, confirmed by Dual-luciferase reporter assay.CCAT1 knockdown reversed the tumor-promoting of miR-33a inhibitor.
Annotations
External Annotation for CCAT1 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
