Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGlioblastoma
CeRNA1H19[LncRNA]
miRNAmiR-181d[miRNA]
CeRNA2b-catenin[mRNA]
Tissue/Cell lineU87, U251, Ln229, U373 And U118
SpecieMus musculus (mouse)
CitationSci Rep 2017 Mar 22 7, 45029 doi:10.1038/srep45029 PMID:28327666
Reference title
Hypoxia induces H19 expression through direct and indirect Hif-1a activity, promoting oncogenic effects in glioblastoma.
Experimental verification
luciferase reporter assays;qRT-PCR
Functional description
After transfecting a luciferase reporter plasmid harboring the putative miR-181d binding site from H19, the relative luciferase activity decreased in cells transfected with miR-181d mimics but not miR-16-1 mimics,miR-181d overexpression decreased the b-catenin levels, and H19 upregulation facilitated b-catenin accumulation by aborting the inhibition of miR-181d in both U87 and U251 cells.
Annotations
External Annotation for H19 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
