Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHcv-Related Hepatic Fibrosis
CeRNA1LncRNA-ATB[LncRNA]
miRNAmiR-200a[miRNA]
CeRNA2b-catenin[mRNA]
Tissue/Cell lineLiver Tissues,Hepatic Stellate Cells
SpecieHomo sapiens (human)
CitationGene 2017 Jun 30 618, 1-7 doi:10.1016/j.gene.2017.03.008 PMID:28302418
Reference title
LncRNA-ATB/microRNA-200a/b-catenin regulatory axis involved in the progression of HCV-related hepatic fibrosis.
Experimental verification
luciferase reporter assays;qRT-PCR
Functional description
LncRNA-ATB was up-regulated in fibrotic liver tissues and activated LX-2 cells treated with CM from HepG2-CORE cells. Dual luciferase reporter assays confirmed that lncRNA-ATB contained common binding sites for miR-200a and b-catenin. Decreased expression of miR-200a and increased expression of b-catenin were observed in liver tissues of patients with HCV-related hepatic fibrosis and activated HSCs. Knockdown of lncRNA-ATB could down-regulate b-catenin expression by up-regulating the endogenous miR-200a and suppress the activation of LX-2 cells.
Annotations
External Annotation for LncRNA-ATB |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
