Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHepatocellular Carcinoma
CeRNA1STARD13[Coding-mRNA]
miRNAmiR-203[miRNA]
CeRNA2FAS[mRNA]
Tissue/Cell lineHepg2 And Huh7
SpecieHomo sapiens (human)
CitationBiotechnol Lett 2017 Feb 39, 207-217 doi:10.1007/s10529-016-2253-6 PMID:27844181
Reference title
STARD13 promotes hepatocellular carcinoma apoptosis by acting as a ceRNA for Fas.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
To understand the molecular mechanisms of STARD13 3'-UTR- mediated cellular apoptosis, miRNA binding sites were predicted in the 3'-UTRs of STARD13 and Fas and nine common miRNAs were identified to bind to the 3'-UTRs of STARD13 and Fas. Thus we assumed that STARD13 3'-UTR could act as a ceRNA for Fas. The hypothesis was further tested by confirming that STARD13 3'-UTR modulates Fas expression in a miRNA- and 3'-UTR-dependent way.
Annotations
External Annotation for STARD13 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
