Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieGlioma
CeRNA1Circ-TTBK2[Circular RNA]
miRNAmiR-217[miRNA]
CeRNA2HNF1B[mRNA]
Tissue/Cell lineU87 And U251
SpecieHomo sapiens (human)
CitationJ Hematol Oncol 2017 Feb 20 10, 52 doi:10.1186/s13045-017-0422-2 PMID:28219405
Reference title
TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1b/Derlin-1 pathway
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay;RNA immunoprecipitation
Functional description
Enhanced expression of circ-TTBK2 promoted cell proliferation, migration, and invasion, while inhibited apoptosis. MiR-217 was downregulated in glioma tissues and cell lines. We also found that circ-TTBK2, but not linear TTBK2, acted asmiR-217 sponge in a sequence-specific manner. In addition, upregulated circ-TTBK2 decreased miR-217 expression and there was a reciprocal negative feedback between them in an Argonaute2-dependent manner. Moreover, reintroduction of miR-217 significantly reversed circ-TTBK2-mediated promotion of glioma progression. HNF1b was a direct target of miR-217, and played oncogenic role in glioma cells.
Annotations
External Annotation for Circ-TTBK2 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
