Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColorectal Cancer
CeRNA1CRNDE[LncRNA]
miRNAmiR-181a-5p[miRNA]
CeRNA2b-catenin[mRNA]
Tissue/Cell lineHct116 And Sw480
SpecieMus musculus (mouse)
CitationMol Cancer 2017 Jan 13 16, 9 doi:10.1186/s12943-017-0583-1 PMID:28086904
Reference title
The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/b-catenin signaling.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
CRNDE knockdown and miR-181a-5p overexpression in CRC cell lines led to inhibited cell proliferation and reduced chemoresistance. We also determined that b-catenin and TCF4 were inhibitory targets of miR-181a-5p, and that Wnt/b-catenin signaling was inhibited by both CRNDE knockdown and miR-181a-5p overexpression.
Annotations
External Annotation for CRNDE |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
