Basic Information
Regular Relationship :
Phenotype/DiseaseSpeciePhysiological Cardiac Hypertrophy
CeRNA1miR-199-sponge[Artifically engineered RNA]
miRNAmiR-199a-5p[miRNA]
CeRNA2PGC1A[mRNA]
Tissue/Cell lineMouse Heart
SpecieMus musculus (mouse)
CitationCardiovasc Res 2016 May 15 110, 258-67 doi:10.1093/cvr/cvw052 PMID:26976621
Reference title
miR-199-sponge transgenic mice develop physiological cardiac hypertrophy.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
We generated a sponge transgenic mouse model with a specific disruption of miR-199 in the heart. To our surprise, we found that knockdown of endogenous miR-199 caused physiological cardiac hypertrophy characterized by an increased heart weight and cardiomyocyte size, but with normal cardiac morphology and function. Furthermore, we also identified PGC1a as the target gene of the miR-199 family, and PGC1a was also increased in sponge transgenic mice.
Annotations
External Annotation for miR-199-sponge |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
