Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieColon Cancer
CeRNA1miR-130a sponge[Artifically engineered RNA]
miRNAmiR-130a[miRNA]
CeRNA2NA[mRNA]
Tissue/Cell lineHt126
SpecieHomo sapiens (human)
CitationSci Rep 2016 Dec 15 6, 38306 doi:10.1038/srep38306 PMID:27974852
Reference title
Four microRNAs Signature for Survival Prognosis in Colon Cancer using TCGA Data.
Experimental verification
vector transfection
Functional description
We used HT126 colon cancer cells in the study to explore the anti-cancer effects of miR-130a sponge. In the study, cell growth assay showed miR-130a sponge inhibited colon cancer cells growth in a dose dependent manner in 96h. When it combined with anti-cancer drug 5-FU, the miR-130a sponge sensitized the anti-cancer drug effect of 5-FU to block cancer cell growth in 96h.
Annotations
External Annotation for miR-130a sponge |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
