Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieTendon Injures
CeRNA1H19[LncRNA]
miRNAmiR-29b-3p[miRNA]
CeRNA2TGFB1[mRNA]
Tissue/Cell lineMouse Tendon Defect Model
SpecieMus musculus (mouse)
CitationFaseb j 2017 Mar 31, 954-964 doi:10.1096/fj.201600722R PMID:27895107
Reference title
Long noncoding RNA H19 accelerates tenogenic differentiation and promotes tendon healing through targeting miR-29b-3p and activating TGF-b1 signaling.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
Stable overexpression of H19 significantly accelerated TGF-b1-induced tenogenic differentiation in vitro and accelerated tendon healing in a mouse tendon defect model. H19 directly targeted miR-29b-3p, which is considered to be a negative regulator of tenogenesis. Furthermore, miR-29b-3p directly suppressed the expression of TGF-b1 and type I collagen, thereby forming a novel regulatory feedback loop between H19 and TGF-b1 to mediate tenogenic differentiation.
Annotations
External Annotation for H19 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
