Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCardiac Fibrosis
CeRNA1AAV9[Artifically engineered RNA]
miRNAmiR-433[miRNA]
CeRNA2AZIN1[mRNA]
Tissue/Cell lineHeart Tissues
SpecieMus musculus (mouse)
CitationTheranostics 2016 6, 2068-2083 doi:10.7150/thno.15007 PMID:27698941
Reference title
Crucial Role of miR-433 in Regulating Cardiac Fibrosis.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
Decreased level of AZIN1 activated TGF-b1 while down-regulation of JNK1 resulted in activation of ERK and p38 kinase leading to Smad3 activation and ultimately cardiac fibrosis. Importantly, systemic neutralization of miR-433 or adeno-associated virus 9 (AAV9)-mediated cardiac transfer of a miR-433 sponge attenuated cardiac fibrosis and ventricular dysfunction following myocardial infarction.
Annotations
External Annotation for AAV9 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
