Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieLung Cancer
CeRNA1hsa_circ_0008234[Circular RNA]
miRNAmiR-574-5p[miRNA]
CeRNA2RND3[mRNA]
Tissue/Cell lineLUAC cell lines(H1299 and PC9)
SpecieHomo sapiens (human)
CitationCell Death Discov 2021 May 28 7, 123 doi:10.1038/s41420-021-00512-1 PMID:34050132
Reference title
hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p
Experimental verification
qRT-PCR
Functional description
In terms of its possible mechanism, circ_0008234 mainly was present in the cytoplasm and competed with miR-574-5p to regulate RND3 (Rho family GTPase 3). Our results revealed that circ_0008234 inhibited the progression of LUAC through a competing endogenous RNA (ceRNA)-based mechanism and provided potential biomarkers and therapeutic targets for LUAC treatment.
Annotations
External Annotation for hsa_circ_0008234 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
