Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieLung Cancer
CeRNA1cir-ITCH[Circular RNA]
miRNAmiR-214[miRNA]
CeRNA2ITCH[mRNA]
Tissue/Cell lineA549 And Nic-H460
SpecieHomo sapiens (human)
CitationBiomed Res Int 2016 2016, 1579490 doi:10.1155/2016/1579490 PMID:27642589
Reference title
Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/b-Catenin Pathway.
Experimental verification
qRT-PCR;Western blot assay
Functional description
cir-ITCH was enhanced in different lung cancer cell lines, A549 and NIC-H460. Ectopic expression of cir-ITCH markedly elevated its parental cancer-suppressive gene, ITCH, expression and inhibited proliferation of lung cancer cells. Molecular analysis further revealed that cir-ITCH acted as sponge of oncogenic miR-7 and miR-214 to enhance ITCH expression and thus suppressed the activation of Wnt/b-catenin signaling.
Annotations
External Annotation for cir-ITCH |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
